Solid phase synthesis of complex natural products and libraries thereof

Biopolymers ◽  
2001 ◽  
Vol 60 (3) ◽  
pp. 171-193 ◽  
Author(s):  
K. C. Nicolaou ◽  
J. A. Pfefferkorn
Keyword(s):  
Natural Products ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Combinatorial chemistry of natural products: Solid phase synthesis of D- and L-cycloserine derivatives

Tetrahedron ◽  
1998 ◽  
Vol 54 (52) ◽  
pp. 15879-15890 ◽  
Author(s):  
Mikhail F. Gordeev ◽  
Gary W. Luehr ◽  
Hon C. Hui ◽  
Eric M. Gordon ◽  
Dinesh V. Patel
Keyword(s):  
Natural Products ◽  
Combinatorial Chemistry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

scholarly journals Traceless Solid-Phase Synthesis of Ketones via Acid-Labile Enol Ethers: Application in the Synthesis of Natural Products and Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1406 ◽  
Author(s):  
Eva Schütznerová ◽  
Anna Krchňáková ◽  
Viktor Krchňák
Keyword(s):  
Natural Products ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Tetramic Acid ◽  
Enol Ethers ◽  
Phase Synthesis ◽  
Wang Resin ◽  
Synthetic Strategy ◽  
Solid Phase Organic Synthesis ◽  
Acid Labile

In solid-phase organic synthesis, Wang resin is traditionally used for the immobilization of acids, alcohols, phenols, and amines. We report the use of Wang resin for the traceless synthesis of ketones via acid-labile enol ethers. We demonstrate the practicality of this synthetic strategy on the solid-phase synthesis of pyrrolidine-2,4-diones, which represent the core structure of several natural products, including tetramic acid. Base-triggered condensation of pyrrolidine-2,4-diones yielded 4-hydroxy-1,1′,2′,5-tetrahydro-2H,5′H-[3,3′-bipyrrole]-2,5′-diones.

Enzyme-Labile Protecting Groups for the Synthesis of Natural Products: Solid-Phase Synthesis of Thiocoraline

2013 ◽  
Vol 125 (22) ◽  
pp. 5838-5842 ◽  
Author(s):  
Judit Tulla-Puche ◽  
Miriam Góngora-Benítez ◽  
Núria Bayó-Puxan ◽  
Andrés M. Francesch ◽  
Carmen Cuevas ◽  
...  
Keyword(s):  
Natural Products ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Protecting Groups ◽  
Phase Synthesis
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